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Research programme 03
Isoform-specific p53 biology
We define how distinct p53 protein isoforms divide transactivation, transrepression and germline functions.
A single p53 locus can generate protein isoforms with different regulatory capacities. Isoform-specific knockouts in Drosophila allow the laboratory to separate functions that are dispensable for stress-induced activation from those required for constitutive repression and proper germ-cell development.
The group is extending this isoform lens to conserved mechanisms relevant to mammalian tumor suppression and cancer-associated disruption.
01p53 isoform→
02Target programme→
03Germline function→
04Tumor insight